Homocysteine HPLC Assay Column

The Homocysteine HPLC Assay Column is For Research Use Only

Each column is can be utilized for approximately 500-1000 samples depending on column care and sample type.

Assay Background

Homocysteine is an amino acid, which is produced out of methionine. It is not ingested by nutrition. Homocysteine is rapidly degraded to cysteine when vitamin B6, folic acid and vitamin B12 are sufficiently available. Increased levels of homocysteine will damage heart and blood vessels. Meanwhile it is an established risk marker for cardiovascular disease. US studies demonstrate that 40% of heart attacks are caused by increased homocysteine levels. Also the risk for stroke is increased by elevated homocysteine concentrations in plasma. A participation of homocysteine in Alzheimer and Parkinson diseases are under discussion.

The reason for high homocysteine levels are a lack of vitamin B6, folic acid and vitamin B12 and/or a defect in the enzyme cystathione synthase, which catalysis the reaction from homocysteine to cysteine.  Increased homocysteine concentration have been found to be reduced by the supplementation with folic acid, vitamin B6 and vitamin B12.

The Eagle Biosciences Homocysteine HPLC Assay Kit makes it possible to determine homocysteine in an easy, fast and precise method. The Homocysteine HPLC Assay kit includes all reagents for preparation and separation of the samples with exception of the columns (IC2801rp) and the controls (IC2801ko). Both can be supplied by Eagle Biosciences.  Beside the complete test kits it is possible to order all components separately. Please request our single component price list.

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