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商品详细鹰嘴豆/羟基吡啶交联高效液相色谱柱/IC3201rp
鹰嘴豆/羟基吡啶交联高效液相色谱柱/IC3201rp
鹰嘴豆/羟基吡啶交联高效液相色谱柱/IC3201rp
商品编号: IC3201rp
品牌: EagleBio
市场价: ¥0.00
美元价: 0.00
产地: 美国(厂家直采)
公司:
产品分类: 计数测量
公司分类: Count_measurement
联系Q Q: 3392242852
电话号码: 4000-520-616
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商品介绍

Hydroxypyridinium Crosslinks HPLC Column

The Hydroxypyridinium Crosslinks HPLC Column is For Research Use Only

Each column is can be utilized for approximately 500-1000 samples depending on column care and sample type.


Assay Background

Pyridinium and deoxypyridinium are built as intramolecular crosslinkers during the maturation of collagen. During bone resorption collagen is degraded and the pyridinium-crosslinks are excreted. They are not re-utilized by the body and excreted in the urine. The crosslinks are not released during the de novo synthesis of collagen. They are specific for resorptive processes. Neither PYD nor DPD are taken up by nutrition. Therefore the determination of the crosslinks is independent from the diet. PYD is found in cartilage, ligaments and bone, whereas DPD is rather specific for bone.

The crosslink excretion shows a strong circadian rhythm with a maximum in the early morning hours. Reliable data can be obtained with a 24h or a creatinine corrected morning urine. An elevated crosslink excretion is shown in osteoporotic women. Crosslink levels decrease during treatment with estrogen (Seibel et al. 1994). Therefore they are suited for therapy monitoring (Ganero et al. 1994). The measurement of pyridinium crosslinks is an independent predictor for future bone fractures (Ganero et al. 1995). Increased crosslink concentrations are also described in patients with Paget’s disease, primary hyperparathyroidism and bone metastasis.

Hydroxypyridinium Crosslinks HPLC Assay kit application for the pyridinium crosslinks makes it possible to determine pyridinium and deoxypyridinium in an easy, fast and precise method. The Hydroxypyridinium Crosslinks HPLC Assay kit includes all reagents in a ready to use form for preparation and separation of the samples with exception of the columns (IC3201rp) and the controls (IC3201ko). Both can be supplied separately by Eagle Biosciences. Beside the complete test kits it is possible to order all components separately. Please request our single component price list.


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品牌介绍
Eagle Biosciences已迅速成为全球研究和临床社区免疫测定,抗体和蛋白质的先进供应商。我们的员工在研究和诊断行业拥有超过25年的经验,在商业化和分销方面拥有超过10年的经验。除了分销来自20多个欧洲组织的产品外,我们还提供EagleBio开发的产品。通过所有这些产品,我们将主要专注于提供有助于医学研究和临床实验室的深奥和创新产品eaglebio新产品介绍FluoBolt-Noggin Fluorescence Immunoassay荧光免疫法SKU:FIA-1702-A6-1分类:骨代谢氟硼酸盐- Noggin Fluorescence Immunoassay是用于定量测定人血清或血浆中NOGGIN的方法。FluoBolt™-Noggin荧光免疫分析与骨肿瘤、强直性脊柱炎和肺动脉高压等疾病有关。